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血清介导的针对羊布鲁氏菌的免疫细胞反应。IV. 厌氧条件下巨噬细胞的感染

Serum-mediated immune cellular responses to Brucella melitensis. IV. Infection of macrophages under anaerobic conditions.

作者信息

Ralston D J, Elberg S S

出版信息

J Bacteriol. 1969 Feb;97(2):471-80. doi: 10.1128/jb.97.2.471-480.1969.

Abstract

Immune mechanisms active against Brucella were studied under conditions of oxygen deficiency. B. melitensis grew in rabbit serum-Tyrode medium flooded with N(2) and CO(2) gas mixtures. Immune sera from rabbits injected with B. melitensis strain Rev I possessed growth-inhibitory activity that operated in anaerobic environments against Rev I and virulent strain 6015. When mixed with macrophages, immune sera mediated even greater inhibition of bacterial growth and slowed the spread of infection throughout the tissue culture. Although under anaerobic conditions the rate of phagocytosis was reduced, the macrophages in immune serum killed significant percentages of Brucella, suggesting that an antibacterial mechanism had been activated. Sonic extracts of macrophages prepared and tested under anaerobic conditions depressed the growth rate of strain Rev I. The extracts, however, exhibited no immediate killing capacity when tested in Tyrode solution. A factor from serum was required for depression of the growth rate.

摘要

在缺氧条件下研究了抗布鲁氏菌的免疫机制。羊种布鲁氏菌在充满氮气和二氧化碳混合气体的兔血清 - 台氏液培养基中生长。用羊种布鲁氏菌Rev I菌株免疫的兔血清具有生长抑制活性,该活性在厌氧环境中对Rev I和强毒株6015起作用。当与巨噬细胞混合时,免疫血清介导对细菌生长的更强抑制,并减缓感染在整个组织培养物中的传播。虽然在厌氧条件下吞噬作用速率降低,但免疫血清中的巨噬细胞杀死了相当比例的布鲁氏菌,表明一种抗菌机制已被激活。在厌氧条件下制备和测试的巨噬细胞超声提取物抑制了Rev I菌株的生长速率。然而,当在台氏液中测试时,提取物没有立即杀伤能力。抑制生长速率需要血清中的一种因子。

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