Hedgecock L W, Torres A
J Bacteriol. 1969 Feb;97(2):893-9. doi: 10.1128/jb.97.2.893-899.1969.
A study was made of the pathogenic properties of the Trudeau Culture Collection strain (T-67) of Mycobacterium sp. 607 for mice. The organism was highly pathogenic for CF1 mice upon intravenous injection. The animals succumbed soon after intravenous injection of a 14 x 10(6) viable cellular units. The T-67 strain proliferated in the kidneys of the animals but was unable to reproduce in the lungs, liver, and spleen. Destruction of the organisms in the latter organs commenced 24 hr after injection. Tissue bacterial counts showed that the mycobacteria were similarly destroyed in the kidneys after an interval of from 7 to 9 days after injection of the organisms. Histopathological examination of the tissues indicated that the lethal effects of the organism were due primarily to kidney damage. The liver, lungs, and spleen were similarly involved but to a lesser degree. The unique characteristics of the T-67 strain of Mycobacterium sp. 607 are discussed.
对分枝杆菌属607号菌株的特鲁多培养保藏菌株（T - 67）对小鼠的致病特性进行了研究。该菌静脉注射对CF1小鼠具有高度致病性。静脉注射14×10⁶个活细胞单位后，动物很快死亡。T - 67菌株在动物肾脏中增殖，但无法在肺、肝和脾中繁殖。注射后24小时，后述器官中的细菌开始被破坏。组织细菌计数显示，注射该菌后7至9天，肾脏中的分枝杆菌同样被破坏。组织的组织病理学检查表明，该菌的致死作用主要是由于肾脏损伤。肝脏、肺和脾也有类似病变，但程度较轻。讨论了分枝杆菌属607号菌株T - 67的独特特征。
