正常男性对贫血反应时骨髓生成及网织红细胞成熟的特征
Characteristics of marrow production and reticulocyte maturation in normal man in response to anemia.
作者信息
Hillman R S
出版信息
J Clin Invest. 1969 Mar;48(3):443-53. doi: 10.1172/JCI106001.
Abstract
Erythropoiesis in normal man was studied during periods of phlebotomy-induced anemia of varying severity. This study permitted a comparison of marrow production measurements over a wide range of marrow production levels. As long as the serum iron remained above 50 mug/100 ml, measurements of plasma iron turnover provided an excellent index of marrow production at all levels of red cell production. In contrast, the absolute reticulocyte count demonstrated a poor correlation with the other measurements. This was shown to be the result of a prolongation of the time required for circulating reticulocytes to lose their reticulum, which correlated with the severity of the anemia. For the clinical application of the reticulocyte count as a measurement of marrow production, an adjustment must be made for this alteration in the circulating reticulocyte maturation time.
摘要
在不同严重程度的放血诱导贫血期间，对正常男性的红细胞生成进行了研究。这项研究允许在广泛的骨髓生成水平范围内比较骨髓生成测量值。只要血清铁保持在50微克/100毫升以上，血浆铁周转率的测量在所有红细胞生成水平上都能很好地反映骨髓生成情况。相比之下，绝对网织红细胞计数与其他测量值的相关性较差。这被证明是循环中网织红细胞失去网状结构所需时间延长的结果，这与贫血的严重程度相关。对于将网织红细胞计数作为骨髓生成测量的临床应用，必须针对循环中网织红细胞成熟时间的这种改变进行调整。
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