Olafsson S, Hyatt R E
J Clin Invest. 1969 Mar;48(3):564-73. doi: 10.1172/JCI106015.
We have examined the interrelationships among transpulmonary pressure, flow, and volume during exhausting exercise in 10 normal adult males. Expiratory transpulmonary pressures during exercise were compared with flow-limiting pressures measured at rest by two techniques. In no case did pressures developed during exercise exceed to an appreciable extent the flow-limiting pressures. This indicates that, during near-maximal exercise, ventilation remains efficient as judged in terms of the pressure-volume relationships of the lung. The mechanical properties of the lung do not appear to limit ventilation during exhausting exercise in normal subjects. We could find no relationship between the magnitude of transpulmonary pressure and exercise limitation. There was no evidence that lung mechanics changed during exhausting exercise in normal subjects. The two methods for estimating expiratory flow-limiting pressures, the orifice technique and the isovolume pressure-flow method, gave similar results.
我们研究了10名正常成年男性在力竭运动期间跨肺压、流量和容积之间的相互关系。将运动期间的呼气跨肺压与通过两种技术在静息时测得的流量限制压进行了比较。在任何情况下，运动期间产生的压力都没有明显超过流量限制压。这表明，就肺的压力-容积关系而言，在接近最大运动期间，通气仍然是有效的。在正常受试者力竭运动期间，肺的力学特性似乎不会限制通气。我们没有发现跨肺压大小与运动受限之间的关系。没有证据表明正常受试者在力竭运动期间肺力学发生了变化。估计呼气流量限制压的两种方法，即孔口技术和等容压力-流量法，给出了相似的结果。
