Potter W A, Olafsson S, Hyatt R E
J Clin Invest. 1971 Apr;50(4):910-9. doi: 10.1172/JCI106563.
The interrelationships among transpulmonary pressure, flow, and volume during exhausting exercise were studied in 12 males with chronic obstructive lung disease. Expiratory pressure during exercise was compared with flow-limiting pressure (P(max)) measured at rest. In 11 patients, expiratory pressure during exercise exceeded P(max), indicating that ventilation became mechanically inefficient. P(max) values of the patients were lower than those of normal subjects. Evidence of expiratory flow augmentation during exercise was noted in two subjects. Since 10 subjects achieved maximal expiratory flow predicted from flow-volume curves when heart rate was not maximal, we conclude that exercise capacity in most subjects was clearly limited by the deranged ventilatory apparatus. Elevations in mean intrathoracic pressure during exercise also may interfere with venous return and impose an additional limitation.
对12名慢性阻塞性肺疾病男性患者在力竭运动期间肺跨压、气流和容积之间的相互关系进行了研究。将运动期间的呼气压力与静息时测得的流量限制压力（P(max)）进行比较。11名患者运动期间的呼气压力超过了P(max)，表明通气在机械方面变得低效。患者的P(max)值低于正常受试者。两名受试者出现了运动期间呼气气流增加的证据。由于10名受试者在心率未达到最大值时就达到了流量-容积曲线预测的最大呼气流量，我们得出结论，大多数受试者的运动能力明显受到通气装置紊乱的限制。运动期间平均胸内压升高也可能干扰静脉回流并造成额外限制。
