A serum factor in aspirin intolerance disease.

Direct and indirect intradermal serum challenge with aspirin intolerant sera in both aspirin tolerant and intolerant patients demonstrated a heat, cold and storage stable serum factor capable of inducing acute anti-hemostatic effects and in some aspirin intolerant patients exacerbation of brief induced clinical symptoms. The data supports a hypothesis for possible induced, conformationally altered gamma globulin resulting from low molecular weight chemical exposures such as aspirin with ensuing recognition by a genetically determined subpopulation of B-lymphocytes with surface membrane receptors avid for the Fc portion of altered gamma globulin or some conformationally altered gamma globulin fraction leading to immune and/or interprotein complexes with subsequent alterations of adrenergic, cholinergic and/or metabolic pharmacologic pathways.