Tajima K, Tokuyama K, Morikawa A, Mochizuki H, Kuroume T
Department of Pediatrics, Gunma University School of Medicine, Japan.
Ann Allergy. 1989 Mar;62(3):190-3.
Two cases of aspirin-intolerant asthma whose polymorphonuclear leukocytes demonstrated hypersensitivity to sulpyrin in vitro were reported. The patients were 14- and 15-year-old girls. Aspirin and sulpyrin intolerance were confirmed by aspirin oral provocation test and bronchial sulpyrin inhalation provocation test. In those intolerant patients, preincubation of polymorphonuclear leukocytes with sulpyrin enhanced the calcium ionophore A23187-induced leukotriene C4 production as compared with those of healthy adults and aspirin-tolerant asthma.
报告了两例阿司匹林不耐受性哮喘病例，其多形核白细胞在体外对磺吡酮表现出超敏反应。患者为14岁和15岁的女孩。通过阿司匹林口服激发试验和支气管磺吡酮吸入激发试验证实了阿司匹林和磺吡酮不耐受。在那些不耐受的患者中，与健康成年人和阿司匹林耐受型哮喘患者相比，多形核白细胞与磺吡酮预孵育增强了钙离子载体A23187诱导的白三烯C4生成。
