成年和幼年大鼠脑体外核糖核酸的生物合成
Ribonucleic acid biosynthesis in adult and infant rat brain in vitro.
作者信息
Itoh T, Quastel J H
出版信息
Science. 1969 Apr 4;164(3875):79-80. doi: 10.1126/science.164.3875.79.
The rate of biosynthesis of ribonucleic acid (as judged by the rate of incorporation of uridine into ribonucleic acid) in infant and adullt rat brain cortex slices, incubated (aerobically in tile presenice of various substrates, is directly proportionial to the adenosine triphosphate concentration. This suggests that the adenosine triphosphate concentration is one of the factors involved in the control of ribonucleic acid biosynthesis in infant and adult rat brain. Acetoacetate or beta-hydroxybutyrate is about 70 percent as effective as glucose, with both infant and adult brain, for the promotion of ribonucleic acid biosynthesis. but they are considerably mnore effective than succinate in infant brain than in adult brain.
在有氧条件下，将婴儿和成年大鼠大脑皮层切片与各种底物一起孵育，核糖核酸的生物合成速率（通过尿苷掺入核糖核酸的速率来判断）与三磷酸腺苷浓度成正比。这表明三磷酸腺苷浓度是参与控制婴儿和成年大鼠大脑核糖核酸生物合成的因素之一。对于促进核糖核酸的生物合成，乙酰乙酸或β-羟基丁酸在婴儿和成年大脑中的效果约为葡萄糖的70%，但它们在婴儿大脑中比在成年大脑中对促进核糖核酸生物合成的效果要显著得多。
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