两种组氨酸脱羧酶抑制剂对大鼠胃液分泌的影响。
The effect of two inhibitors of histidine decarboxylase on gastric secretion in the rat.
作者信息
Megazzini P, Bacciarelli C
出版信息
Arzneimittelforschung. 1977;27(3):620-3.
PMID:577431
Abstract
The effects of the hydrazino-analogue of histidine (HH) and DL-gamma-N(1,2,3,4-tetrahydroisoquinolyl)-alpha-hydrazino-butyric acid (AIS 48), two inhibitors of histidine decarboxylase, and atropine on gastric secretion stimulated by histamine and pentagastrin were studied in the perfused rat stomach. The results confirm that the mechanism of action of the physiological polypeptide is mediated, and that the inhibition of histidine decarboxylase can be useful means to control gastric secretion.
摘要
在灌注大鼠胃中，研究了组氨酸脱羧酶的两种抑制剂——组氨酸肼类似物（HH）和DL-γ-N（1,2,3,4-四氢异喹啉基）-α-肼基丁酸（AIS 48）以及阿托品对组胺和五肽胃泌素刺激的胃酸分泌的影响。结果证实，生理多肽的作用机制是通过介导的，并且抑制组氨酸脱羧酶可能是控制胃酸分泌的有效手段。
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