Brunner P, Kaduk B, Gunselmann W, Husemann B
Arzneimittelforschung. 1977;27(3):635-7.
1 and 3 h after i.p. application of Ozothin, an oxidation product of Bordeaux terpin oil, in rats there is a significant increase in goblet cells both totally and in the tightly filled ones (respectively in the villi of the small intestine). Double i.v. injection of therapeutic doses of Ozothin (first 14 h and booster 2 h preoperatively) induces a significant decrease in the number of the tightly filled goblet cells. These contradictory results may partly be explained as an initially timed ischesis of mucigenous glands by Ozothin. Statistically significant differences among the different series of tests could be found only in the epithelium of the villi. In the crypts there were similar results lacking statistical significance.
给大鼠腹腔注射波尔多萜品油的氧化产物奥索辛后1小时和3小时，小肠绒毛中杯状细胞总数及充盈紧密的杯状细胞数量均显著增加。术前14小时首次静脉注射治疗剂量的奥索辛，术前2小时再次静脉注射，会使充盈紧密的杯状细胞数量显著减少。这些相互矛盾的结果部分可以解释为奥索辛最初使黏液腺出现定时缺血。不同系列测试之间具有统计学意义的差异仅在绒毛上皮中发现。隐窝中的结果相似，但缺乏统计学意义。
