某些抗生素对线粒体、红细胞及人工磷脂膜的作用。诱导质子通透性的作用。
The action of certain antibiotics on mitochondrial, erythrocyte and artificial phospholipid membranes. The role of induced proton permeability.
作者信息
Henderson P J, McGivan J D, Chappell J B
出版信息
Biochem J. 1969 Feb;111(4):521-35. doi: 10.1042/bj1110521.
Abstract
- The action of the antibiotics enniatin A, valinomycin, the actin homologues, gramicidin, nigericin and dianemycin on mitochondria, erythrocytes and smectic mesophases of lecithin-dicetyl hydrogen phosphate was studied. 2. These antibiotics induced permeability to alkali-metal cations on all three membrane systems. 3. The ion specificity on each membrane system was the same. 4. Enniatin A, valinomycin and the actins did not induce permeability to protons, whereas nigericin and dianemycin rendered all three membrane systems freely permeable to protons. 5. Several differences were noted between permeability induced by nigericin and that induced by gramicidin. 6. The action of all these antibiotics on mitochondrial respiration could be accounted for by changes in passive ion permeability of the mitochondrial membrane similar to those induced in erythrocytes and phospholipid membranes, if it is assumed that a membrane potential is present in respiring mitochondria.
摘要
- 研究了恩镰孢菌素A、缬氨霉素、肌动蛋白同系物、短杆菌肽、尼日利亚菌素和地恩霉素对线粒体、红细胞以及卵磷脂 - 磷酸二鲸蜡酯近晶中间相的作用。2. 这些抗生素在所有三种膜系统上均诱导了对碱金属阳离子的通透性。3. 每个膜系统上的离子特异性相同。4. 恩镰孢菌素A、缬氨霉素和肌动蛋白不诱导质子通透性，而尼日利亚菌素和地恩霉素使所有三种膜系统对质子自由通透。5. 尼日利亚菌素诱导的通透性与短杆菌肽诱导的通透性之间存在若干差异。6. 如果假定呼吸线粒体中存在膜电位，那么所有这些抗生素对线粒体呼吸的作用可以通过线粒体膜被动离子通透性的变化来解释，这种变化类似于在红细胞和磷脂膜中诱导的变化。
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