Metabolism of amino acids in protein-calorie-deficient rats.
作者信息
McFarlane I G, Von Holt C
出版信息
Biochem J. 1969 Feb;111(4):557-63. doi: 10.1042/bj1110557.
Abstract
The overall oxidative degradation of leucine and phenylalanine, measured in vivo in rats fed on a 2%-casein diet for 8 weeks, is markedly decreased as compared with controls, whereas that of glutamate and alanine is apparently unaffected. The decrease in leucine degradation is due, at least in part, to a block before the formation of 3-methylbutyryl-CoA (isovaleryl-CoA) in the catabolic pathway. This phenomenon is accompanied by increased incorporation of [(14)C]leucine into liver proteins, decreased urinary excretion of leucine and increased urinary excretion of 4-methyl-2-oxopentanoate (alpha-oxoisocaproate) by protein-depleted animals. The results suggest the existence of adaptive mechanisms that function to conserve an indispensable carbon skeleton.
摘要
相似文献
1
Metabolism of amino acids in protein-calorie-deficient rats.
Biochem J. 1969 Feb;111(4):557-63. doi: 10.1042/bj1110557.
2
Hypoglycin A: a specific inhibitor of isovaleryl CoA dehydrogenase.
Proc Natl Acad Sci U S A. 1971 Jan;68(1):20-4. doi: 10.1073/pnas.68.1.20.
3
Amino acid levels in plasma, liver, and skeletal muscle during protein deprivation.
Am J Physiol. 1973 Aug;225(2):408-14. doi: 10.1152/ajplegacy.1973.225.2.408.
4
[In vivo protein synthesis in the pancreas and liver of normal rats and rats deficient in, or recovering from deficiency in, lysine and threonine].
Bull Soc Chim Biol (Paris). 1967 Jul 27;49(7):759-78.
5
Protein synthesis in liver, muscle, and brain of rats fed a high tyrosine-low protein diet.
J Nutr. 1975 Jul;105(7):885-93. doi: 10.1093/jn/105.7.885.
6
Metabolism of leucine in protein-calorie-deficient rats.
Biochem J. 1969 Feb;111(4):565-71. doi: 10.1042/bj1110565.
7
In vitro accumulation of amino acids by intestinal strips from normal and essential fatty acid-deficient rats.
Biochim Biophys Acta. 1972 Mar 17;255(3):815-21. doi: 10.1016/0005-2736(72)90393-8.
8
Whole-body nitrogen and splanchnic amino acid metabolism differ in rats fed mixed diets containing casein or its corresponding amino acid mixture.
J Nutr. 2001 Jul;131(7):1965-72. doi: 10.1093/jn/131.7.1965.
9
Effect of protein depletion and subsequent repletion on in vivo incorporation of ( 14 C) amino acid into rat liver proteins in riboflavin deficiency.
J Vitaminol (Kyoto). 1972 Jun 10;18(2):73-7. doi: 10.5925/jnsv1954.18.73.
10
Liver polysome profiles and protein synthesis in rats fed a threonine-imbalanced diet.
J Nutr. 1974 Feb;104(2):252-63. doi: 10.1093/jn/104.2.252.
引用本文的文献
1
Serum glycine is associated with regional body fat and insulin resistance in functionally-limited older adults.
PLoS One. 2013 Dec 31;8(12):e84034. doi: 10.1371/journal.pone.0084034. eCollection 2013.
2
Utilization of tyrosine and tryptophan for protein synthesis by undernourished developing rat brain.
Neurochem Res. 1983 Nov;8(11):1471-80. doi: 10.1007/BF00965002.
3
Metabolism of leucine in protein-calorie-deficient rats.
Biochem J. 1969 Feb;111(4):565-71. doi: 10.1042/bj1110565.
4
Modulation of rat skeletal muscle branched-chain alpha-keto acid dehydrogenase in vivo. Effects of dietary protein and meal consumption.
J Clin Invest. 1987 May;79(5):1349-58. doi: 10.1172/JCI112961.
本文引用的文献
1
The effect of diet on the rate of loss of labeled amino acid from tissue proteins.
J Biol Chem. 1952 Mar;195(1):447-52.
2
Differential effects of fasting and protein-free diets on levels of urea cycle enzymes in rat liver.
J Biol Chem. 1962 Jun;237:1921-4.
3
Adaptive characteristics of urea cycle enzymes in the rat.
J Biol Chem. 1962 Feb;237:459-68.
4
Influence of different types of malnutrition on the 14C-lysine metabolism in young rats.
Nature. 1960 Sep 24;187:1117-8. doi: 10.1038/1871117a0.
5
6
[A measuring device for the continuous determination of C14 activity and CO2 concentration in expired air].
Biochem Z. 1961;334:516-23.
7
The effect of a low-protein diet, and of refeeding, on the composition of liver and muscle in the weanling rat.
Br J Nutr. 1958;12(1):74-88. doi: 10.1079/bjn19580011.
8
Enzymatic and metabolic adaptations in animals.
Physiol Rev. 1956 Apr;36(2):164-254. doi: 10.1152/physrev.1956.36.2.164.
9
Effect of protein depletion on the transaminating activities of some rat organs.
J Biol Chem. 1953 Feb;200(2):537-41.
10
Enzymatic preparation of alpha-keto acids.
J Biol Chem. 1952 May;197(1):309-17.
Zotero 插件