Schaper W
Arzneimittelforschung. 1977;27(3a):728-30.
The pathophysiological basis of antianginal therapy with vasodilating agents is critically reviewed. The concept of specific coronary vasodilation should not be pursued in the search for new antianginal agents. Although controlled clinical trials with coronary vasodilators in patients have been successful, no inferences can be drawn as to the concept of coronary vasodilation since most of these compounds vasodilate only the coronaires of experimental animals after i.v. administration but not those of humans after oral ingestion. The stimulating influence of coronary vasodilators on coronary collaterals is an interesting but so far unproven claim. Nitroglycerine dilates the large epicardial coronary vessels. This effect can be of significance in excentric stenoses where the arterial wall is to a small part intact.
对使用血管扩张剂进行抗心绞痛治疗的病理生理基础进行了批判性综述。在寻找新的抗心绞痛药物时，不应追求特异性冠状动脉扩张的概念。尽管在患者中使用冠状动脉血管扩张剂的对照临床试验取得了成功，但由于这些化合物大多仅在静脉给药后能使实验动物的冠状动脉扩张，而口服后对人类冠状动脉无此作用，因此无法就冠状动脉扩张的概念得出任何推论。冠状动脉血管扩张剂对冠状动脉侧支循环的刺激作用是一个有趣但迄今未得到证实的说法。硝酸甘油可扩张心外膜大冠状动脉。这种作用在偏心性狭窄中可能具有重要意义，因为在这种狭窄中动脉壁仅有一小部分是完整的。
