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The hepatotoxicity of 1,3-bis (2-chloroethyl)-1-nitrosurea (BCNU) in rats.

作者信息

Thompson G R, Larson R E

出版信息

J Pharmacol Exp Ther. 1969 Mar;166(1):104-12.

PMID:5776013
Abstract
摘要

相似文献

1
The hepatotoxicity of 1,3-bis (2-chloroethyl)-1-nitrosurea (BCNU) in rats.1,3-双（2-氯乙基）-1-亚硝基脲（卡莫司汀）对大鼠的肝毒性。
J Pharmacol Exp Ther. 1969 Mar;166(1):104-12.
2
Nitrosoureas: 1,3-bis(2-chloroethyl)-1-nitrosourea (NSC-409962; BCNU) and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (NSC-79037; CCNU)--clinical brochure.
Cancer Chemother Rep 3. 1968 Dec;1(1):115-51.
3
A toxicologic comparison of the potency and activity of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) in mice and rats.1,3-双(2-氯乙基)-1-亚硝基脲（卡莫司汀，BCNU）与1-(2-氯乙基)-3-环己基-1-亚硝基脲（洛莫司汀，CCNU）在小鼠和大鼠体内的毒性、效力及活性比较
Toxicol Appl Pharmacol. 1972 Mar;21(3):405-13. doi: 10.1016/0041-008x(72)90160-3.
4
Clinical studies with 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (NSC 79037).1-（2-氯乙基）-3-环己基-1-亚硝基脲（NSC 79037）的临床研究。
Cancer Res. 1971 Mar;31(3):223-7.
5
The effects of 1,3-bis(2-chloroethyl)-1-nitrosurea on survival and cell progression in Chinese hamster cells.
Cancer Res. 1971 Feb;31(2):191-5.
6
[On thetoxic properties of methylnitrosourea].[关于甲基亚硝基脲的毒性特性]
Farmakol Toksikol. 1968 May-Jun;31(3):354-7.
7
Effect of nafenopin on the uptake of bilirubin and sulfobromophthalein by isolated perfused rat liver.萘苯丁酸对离体灌注大鼠肝脏摄取胆红素和磺溴酞钠的影响。
Gastroenterology. 1982 Dec;83(6):1163-9.
8
Teratogenic effects of N-ethyl-N-nitrosourea in the Syrian hamster.
Cancer Res. 1969 May;29(5):1151-5.
9
[Experimental study of the changes induced, with administration of a single dose chlorpromazine, in the chromosecretory function of the liver].
Atti Accad Fisiocrit Siena Med Fis. 1968;17(1):214-8.
10
[Experimental studies for the purpose of establishing the relationship between different doses of chlorpromazine and changes in the chromosecretory function of the liver].
Atti Accad Fisiocrit Siena Med Fis. 1968;17(1):219-21.

引用本文的文献

1
Intratumoral injection of BCNU in ethanol (DTI-015) results in enhanced delivery to tumor--a pharmacokinetic study.在乙醇中进行卡莫司汀瘤内注射（DTI - 015）可增强对肿瘤的递送——一项药代动力学研究。
J Neurooncol. 2005 Jul;73(3):225-38. doi: 10.1007/s11060-004-5675-2.
2
DTI-015 produces cures in T9 gliosarcoma.DTI - 015可治愈T9胶质肉瘤。
Neoplasia. 2003 Jan-Feb;5(1):17-22. doi: 10.1016/s1476-5586(03)80013-1.
3
Distribution of Bratton-Marshall-positive material in mice following intravenous injections of nitrosoureas.静脉注射亚硝基脲后小鼠体内布拉顿 - 马歇尔阳性物质的分布情况。
Cancer Chemother Pharmacol. 1980;4(4):243-8. doi: 10.1007/BF00255268.
4
Distribution of 13N in rat tissues following intravenous administration of nitroso-labeled BCNU.
Cancer Chemother Pharmacol. 1982 Dec;10(1):16-21. doi: 10.1007/BF00257230.
5
The hepatotoxicity of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) in rats. Ultrastructural evidence of a delayed microtubular toxicity.
Cancer Chemother Pharmacol. 1988;22(2):153-62. doi: 10.1007/BF00257314.
6
Studies on the mechanism of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU)-induced hepatotoxicity. II. Biochemical and morphological characterization of the injury and its prevention by phenobarbital.1-（2-氯乙基）-3-环己基-1-亚硝基脲（CCNU）诱导肝毒性的机制研究。II. 损伤的生化和形态学特征以及苯巴比妥对其的预防作用
Cancer Chemother Pharmacol. 1987;19(2):103-8. doi: 10.1007/BF00254560.
7
BCNU-induced quantitative and qualitative changes in hepatic cytochrome P-450 can be correlated with cholestasis.卡氮芥引起的肝脏细胞色素P - 450的定量和定性变化与胆汁淤积有关。
Cancer Chemother Pharmacol. 1990;25(4):227-35. doi: 10.1007/BF00684877.