Sevitt L H, Hoffbrand A V
Br Med J. 1969 Apr 5;2(5648):18-21. doi: 10.1136/bmj.2.5648.18.
Serum folate and vitamin B(12) levels have been measured in 32 patients with renal failure. The initial mean serum folate level was raised above normal in seven patients with acute renal failure whereas the mean level in eight patients severely ill from chronic renal failure was significantly lower than normal. Serum folate levels fell during peritoneal dialysis and rose between dialyses in all these patients and also in one patient who was dialysed for acute pancreatitis.The mean serum B(12) level was raised in patients with both acute and chronic renal failure, but there was no consistent change in serum B(12) level during dialysis.Hypersegmented polymorphs were present in the peripheral blood film of most of the patients with acute or chronic renal failure. Their presence bore no relation to the clinical state, blood urea, serum folate, or serum B(12) level of the patients.
对32例肾衰竭患者的血清叶酸和维生素B12水平进行了测定。7例急性肾衰竭患者的初始血清叶酸平均水平高于正常，而8例慢性肾衰竭重症患者的平均水平显著低于正常。所有这些患者以及1例因急性胰腺炎接受透析的患者在腹膜透析期间血清叶酸水平下降，透析间期升高。急性和慢性肾衰竭患者的血清维生素B12平均水平均升高，但透析期间血清维生素B12水平没有一致变化。大多数急性或慢性肾衰竭患者的外周血涂片中有核分叶过多的多形核白细胞。它们的存在与患者的临床状态、血尿素、血清叶酸或血清维生素B12水平无关。
