• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

兔沙眼病原体所致眼部病变

Ocular lesions induced by the trachoma agent in rabbits.

作者信息

Oh J O, Tarizzo M L

出版信息

J Bacteriol. 1969 Mar;97(3):1042-7. doi: 10.1128/jb.97.3.1042-1047.1969.

DOI:10.1128/jb.97.3.1042-1047.1969
PMID:5776518
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC249812/
Abstract

Injection of the T'ang strain of trachoma agent into the anterior chamber of the rabbit eye caused corneal opacity, characteristic microscopic lesions of the corneal endothelium, varying degrees of neovascularization of the cornea, and uveitis. These ocular changes were agent-specific. The experimental data showed that the microorganism developed in the ocular tissues. The results of this study suggest the possibility of using the rabbit eye as an experimental model for the study of trachoma.

摘要

将沙眼病原体的汤氏菌株注入兔眼前房，可导致角膜混浊、角膜内皮特征性的微观病变、角膜不同程度的新生血管形成以及葡萄膜炎。这些眼部变化具有病原体特异性。实验数据表明该微生物在眼组织中生长。本研究结果提示将兔眼用作沙眼研究的实验模型的可能性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7af6/249812/a635f7fa7acc/jbacter00393-0096-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7af6/249812/514cc3eead93/jbacter00393-0095-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7af6/249812/5632e91cf065/jbacter00393-0095-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7af6/249812/a635f7fa7acc/jbacter00393-0096-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7af6/249812/514cc3eead93/jbacter00393-0095-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7af6/249812/5632e91cf065/jbacter00393-0095-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7af6/249812/a635f7fa7acc/jbacter00393-0096-a.jpg

相似文献

1
Ocular lesions induced by the trachoma agent in rabbits.兔沙眼病原体所致眼部病变
J Bacteriol. 1969 Mar;97(3):1042-7. doi: 10.1128/jb.97.3.1042-1047.1969.
2
Endothelial lesions of rabbit cornea produced by herpes simplex virus.单纯疱疹病毒引起的兔角膜内皮病变
Invest Ophthalmol. 1970 Mar;9(3):196-205.
3
Protective effect of a synthetic polynucleotide complex (poly I: C) on ocular lesions produced by trachoma agent in rabbits.聚肌胞（poly I:C）对沙眼衣原体引起兔眼病变的保护作用。
Infect Immun. 1970 Jun;1(6):566-73. doi: 10.1128/iai.1.6.566-573.1970.
4
Band keratopathy after ocular exposure to visible laser radiation.
Am J Ophthalmol. 1973 Oct;76(4):468-71. doi: 10.1016/0002-9394(73)90732-0.
5
[Dynamic recovery of the corneal endothelial layer of the rabbit in mechanical injuries to the anterior chamber].[兔眼前房机械性损伤后角膜内皮细胞层的动态恢复]
Vestn Oftalmol. 1987 Mar-Apr;103(2):52-6.
6
Ocular infection of rabbits with a Bedsonia isolated from a patient with Reiter's syndrome.
Invest Ophthalmol. 1970 Apr;9(4):256-62.
7
Preliminary observations on ocular effects of high-power, continuous co-2 laser irradiation.
Am J Ophthalmol. 1967 Aug;64(2):209-22. doi: 10.1016/0002-9394(67)92514-7.
8
Demonstration of inflammatory mediator-induced inflammation and endothelial cell damage in the anterior segment of the eye.眼部前段炎症介质诱导的炎症及内皮细胞损伤的证明。
Am J Pathol. 1983 Jan;110(1):1-12.
9
Growth of trachoma agent in primary cultures of rabbit corneal endothelial cells.沙眼病原体在兔角膜内皮细胞原代培养物中的生长。
J Bacteriol. 1969 Mar;97(3):1502-3. doi: 10.1128/jb.97.3.1502-1503.1969.
10
Local adoptive immunity in the eye. II. Ocular response following lymph node allograft and specific antigenic challenge.
Invest Ophthalmol. 1971 Sep;10(9):695-704.

引用本文的文献

1
Protective effect of a synthetic polynucleotide complex (poly I: C) on ocular lesions produced by trachoma agent in rabbits.聚肌胞（poly I:C）对沙眼衣原体引起兔眼病变的保护作用。
Infect Immun. 1970 Jun;1(6):566-73. doi: 10.1128/iai.1.6.566-573.1970.
2
Growth of trachoma agent in primary cultures of rabbit corneal endothelial cells.沙眼病原体在兔角膜内皮细胞原代培养物中的生长。
J Bacteriol. 1969 Mar;97(3):1502-3. doi: 10.1128/jb.97.3.1502-1503.1969.

本文引用的文献

1
The effects of viruses on intraocular tissues; infections with the viruses of herpes simplex, feline agranulocytosis and ornithosis.病毒对眼内组织的影响；单纯疱疹病毒、猫粒细胞缺乏症病毒和鸟疫病毒感染
J Infect Dis. 1950 Jul-Aug;87(1):1-9. doi: 10.1093/infdis/87.1.1.
2
Experimental intraocular infection of guinea pigs with mumps virus.用腮腺炎病毒对豚鼠进行实验性眼内感染。
Proc Soc Exp Biol Med. 1950 Oct;75(1):166-70. doi: 10.3181/00379727-75-18133.
3
[Verification tests concerning the Harisijades You-I trachoma virus on the rabbit cornea].
[关于哈里西贾德斯尤-1型沙眼病毒在兔角膜上的验证试验]
Arch Ophtalmol Rev Gen Ophtalmol. 1961 Oct-Nov;21:645-57.
4
Suppressive effects of pyrilamine maleate and d-lysergic acid diethylamide (LSD-25) on early corneal lesions produced in vitro by Newcastle disease virus (NDV) and compound 48/80.
Virology. 1960 Jan;10:127-43. doi: 10.1016/0042-6822(60)90011-8.
5
ENVIRONMENTAL TEMPERATURE AND THE OCULAR TEMPERATURE GRADIENT.环境温度与眼内温度梯度
Arch Ophthalmol. 1965 Aug;74:237-43. doi: 10.1001/archopht.1965.00970040239022.
6
THE EFFECT OF BACTERIAL ENDOTOXINS ON TOXIC CORNEAL LESIONS PRODUCED BY INFLUENZA AND NEWCASTLE DISEASE VIRUSES.细菌内毒素对流感病毒和新城疫病毒所致毒性角膜损伤的影响。
Am J Pathol. 1965 Feb;46(2):177-95.
7
[STUDIES ON TRACHOMA. 7. COMPARISON OF THE ACTION OF ANTIBIOTICS ON VARIOUS VIRUSES OF THE TRACHOMA GROUP IN EMBRYONATED EGG CULTURES].[沙眼研究。7. 抗生素对鸡胚培养中沙眼组各种病毒作用的比较]
Bull World Health Organ. 1963;29(3):289-98.
8
Investigation of the stability of the trachoma agent.沙眼病原体稳定性的研究
Ann N Y Acad Sci. 1962 Mar 5;98:250-60. doi: 10.1111/j.1749-6632.1962.tb30549.x.
9
Morphological and functional changes in corneal endothelium caused by the toxic effects of influenza and Newcastle disease viruses.流感病毒和新城疫病毒的毒性作用引起的角膜内皮细胞形态和功能变化。
Br J Exp Pathol. 1958 Dec;39(6):601-9.
10
Growth of trachoma agent in primary cultures of rabbit corneal endothelial cells.沙眼病原体在兔角膜内皮细胞原代培养物中的生长。
J Bacteriol. 1969 Mar;97(3):1502-3. doi: 10.1128/jb.97.3.1502-1503.1969.