Zufarov K A, Nadzhimutdinov K N, Tashkhodzhaev P I
Arkh Patol. 1975;37(10):49-55.
The effects of hexachlorocyclohexane (HCHCH) on the weight of the liver, content of protein, glycogen, total lipids as well as morphological and ultrastructural changes in the liver were studied. It was established that HCHCH caused a considerable increase in the weight of the liver, as well as in the levels of protein, glycogen and total lipids, which was particularly pronounced following prolonged administration of HCHCH in the dose 1/50 LD50. Large doses of HCHCH (1/3 LD50) brought about marked dystrophic changes in the liver similar to the type of hydropic degeneration, accumulation of fatty drops in hepatocytes Application of a dose 1/50 LD50 of HCHCH resulted in an increased size of hepatocytes, dystrophic changes being noted only in individual cells. Histochemisally there were revealed high levels of RNA and glycogen in hepatocytes. An-Electron-microscopy study of hepatic cells showed the most manifested changes in the endoplasmatic network of hepatocytes, which were seen in an enlargement of the elements of the smooth endoplasmatic reticulum. A suggestion was put forward that the changes indicated above were associated with a stimulating effect of HCHCH on the microsomic system of hepatocytes, i.e. on the enzymatic systems localized in the smooth endoplasmatic network.
研究了六氯环己烷（HCHCH）对肝脏重量、蛋白质、糖原、总脂质含量以及肝脏形态和超微结构变化的影响。结果表明，HCHCH导致肝脏重量以及蛋白质、糖原和总脂质水平显著增加，在以1/50 LD50剂量长期给予HCHCH后尤为明显。大剂量的HCHCH（1/3 LD50）引起肝脏明显的营养不良性变化，类似于水样变性类型，肝细胞内出现脂肪滴。应用1/50 LD50剂量的HCHCH导致肝细胞体积增大，仅个别细胞出现营养不良性变化。组织化学研究显示肝细胞内RNA和糖原水平较高。对肝细胞的电子显微镜研究表明，肝细胞内质网的变化最为明显，表现为滑面内质网成分增大。有人提出，上述变化与HCHCH对肝细胞微粒体系统的刺激作用有关，即对位于滑面内质网中的酶系统的刺激作用。
