[对双醋谷胺（K-2004）和沙利度胺的致畸-神经毒理学研究]
[Teratologic-neurotoxicologic studies on biglumide (K-2004) and thalidomide].
作者信息
Jurecka W, Lassmann H, Stockinger L
出版信息
Arch Toxicol. 1977 Jun 18;37(2):165-72. doi: 10.1007/BF00293868.
PMID:577687
Abstract
Comparison of the teratogenic and neurotoxic influence of thalidomide with the new hypnosedative preparation Biglumide (K-2004) revealed significant differences. Malformations could be seen only after treatment with thalidomide. Some results concerning the thalidomide-treated group of animals could be interpreted as a retardation of development in the posterior root ganglia.
摘要
对沙利度胺与新型催眠镇静制剂二乙磺酰环己脲（K - 2004）的致畸和神经毒性影响进行比较，结果显示存在显著差异。仅在使用沙利度胺治疗后才出现畸形。关于沙利度胺治疗组动物的一些结果可解释为后根神经节发育迟缓。
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