青蛙皮肤的神经刺激与电特性
Nerve stimulation and electrical properties of frog skin.
作者信息
Lindley B D
出版信息
J Gen Physiol. 1969 Apr;53(4):427-49. doi: 10.1085/jgp.53.4.427.
Abstract
The suitability of frog skin glands as a model for the study of secretory mechanisms in exocrine glands was explored. Periodic voltage clamp was used to determine continually the short-circuit current, chord conductance, and electromotive force of frog skin during neural and pharmacological activation of the skin glands. Both the chord conductance and the short-circuit current increased with glandular activation; the temporal dissociation of these increases suggests that there are at least two separate components to the secretory response. The sensitivity of the secretory electrical changes to changes in the ionic composition of the bathing solutions supports the notion of electrogenic chloride active transport as being basic to the activity of the exocrine glands.
摘要
探讨了蛙皮肤腺作为研究外分泌腺分泌机制模型的适用性。采用周期电压钳技术，在神经和药物激活皮肤腺的过程中，持续测定蛙皮肤的短路电流、弦电导和电动势。随着腺体激活，弦电导和短路电流均增加；这些增加的时间解离表明，分泌反应至少有两个独立的成分。分泌电变化对浴液离子组成变化的敏感性支持了电中性氯离子主动转运是外分泌腺活动基础的观点。
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