[抗病毒剂/第九篇通讯：基于环仲胺的具有病毒静息活性的N-（1-金刚烷基）-硫脲衍生物（作者译）]
[Antiviral agents / 9th communication: virustatically active N-(1-adamantyl)-thiourea derivatives based on cyclic secondary amines (author's transl)].
作者信息
Kreutzberger A, Schröders H H
出版信息
Arzneimittelforschung. 1977;27(5):969-72.
PMID:577881
Abstract
By nucleophilic addition of pyrrolidine (2a), piperidine (2b), 3-hydroxypiperidine (2c), and 4-hydroxypiperidine (2d) on 1-adamantyl-isothiocyanate (1), the N',N'-disubstituted N-(1-adamantyl)-thiourea derivatives 3a, 3b, 3c, and 3d are accessible. Particularly 3d exhibits remarkable antiviral activity vaccinia and herpes virus.
摘要
通过吡咯烷（2a）、哌啶（2b）、3-羟基哌啶（2c）和4-羟基哌啶（2d）对1-金刚烷基异硫氰酸酯（1）进行亲核加成反应，可得到N'，N'-二取代的N-（1-金刚烷基）-硫脲衍生物3a、3b、3c和3d。特别是3d对痘苗病毒和疱疹病毒表现出显著的抗病毒活性。
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