凝血因子的胎盘屏障：其与出生时凝血缺陷及新生儿出血的相关性。
Placental barrier to coagulation factors: its relevance to the coagulation defect at birth and to haemorrhage in the newborn.
作者信息
Cade J F, Hirsh J, Martin M
出版信息
Br Med J. 1969 May 3;2(5652):281-3. doi: 10.1136/bmj.2.5652.281.
Abstract
The placental barrier to coagulation factors was assessed by measuring their levels in maternal venous and neonatal umbilical arterial and venous blood and was found to be largely complete. Detailed coagulation assessments in a large number of term and premature neonates showed that term neonates had a mild coagulation deficiency at birth. Premature neonates had a more definite deficiency, which became more severe with increasing prematurity. Mortality in low birth weight premature infants was associated with a severe coagulation deficiency, and was frequently due to cerebral haemorrhage. It is suggested that the coagulation system of low birth weight infants should be assessed to enable prophylactic treatment of those with a severe deficiency.
摘要
通过测量母体静脉血以及新生儿脐动脉血和脐静脉血中凝血因子的水平，评估胎盘对凝血因子的屏障作用，结果发现该屏障在很大程度上是完整的。对大量足月儿和早产儿进行的详细凝血评估表明，足月儿出生时存在轻度凝血功能缺陷。早产儿的凝血功能缺陷更为明显，且随着早产程度的增加而愈发严重。低出生体重早产儿的死亡率与严重的凝血功能缺陷相关，且常常是由脑出血所致。建议对低出生体重婴儿的凝血系统进行评估，以便对存在严重凝血功能缺陷的婴儿进行预防性治疗。
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Placental barrier to coagulation factors: its relevance to the coagulation defect at birth and to haemorrhage in the newborn.凝血因子的胎盘屏障：其与出生时凝血缺陷及新生儿出血的相关性。
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