吸入麻醉药生物转化的临床意义。

Clinical significance of the biotransformation of inhalation anesthetics.

作者信息

Brown B R

出版信息

South Med J. 1976 May;69(5):554-6. doi: 10.1097/00007611-197605000-00022.

DOI:10.1097/00007611-197605000-00022

Abstract

Inhalation anesthetics, a class of drugs formerly believed to be biologically inert, are now recognized to undergo considerable biotransformation. The viscerotoxicity of certain anesthetics on kidney and liver can be explained in terms of metabolism. The entity of "halothane hepatitis" remains mechanistically and diagnostically a mystery, but if it exists, it could be due to abnormalities of biotransformation.

摘要

吸入性麻醉剂，这一类曾被认为在生物体内无活性的药物，如今已被认识到会经历相当程度的生物转化。某些麻醉剂对肾脏和肝脏的内脏毒性可以从代谢方面进行解释。“氟烷性肝炎”的本质在机制和诊断方面仍是个谜，但如果它确实存在，可能是由于生物转化异常所致。