Fukuda N, Matsumoto T, Umegaki Y, Uchikawa T, Iinuma T
Radioisotopes. 1977 Apr;26(4):209-15. doi: 10.3769/radioisotopes.26.4_209.
Ammonia has been known to be an inducing agent of hepatic coma associated with liver cirrhosis. In order to establish a non-invasive method of investigating the portal circulation and the metabolism of ammonia at liver the following studies were performed, by using cyclotron produced 13N-labeled ammonia and delayed line-camera interphased with on-line computer system. 1) Animal experiment. Dynamic scintigraphy of thoraco-abdominal region of a rabbit after intrasigmoidal as well as intravenous administration of 13N-ammonia were performed. 2) Theoretical consideration on the functional image of liver: According to the results of the animal experiments, a model of ammonia metabolism having the minimal complexity necessary to represent data in the case of intrasigmoidal administration was proposed. Starting from the solution to the differential equation describing the model, relevant parameters characterizing the dynamic curve of liver were duded.
氨一直被认为是与肝硬化相关的肝昏迷的诱发因素。为了建立一种非侵入性方法来研究肝脏的门静脉循环和氨代谢，采用回旋加速器产生的13N标记氨以及与在线计算机系统相结合的延迟线相机进行了以下研究。1）动物实验。在经乙状结肠内和静脉注射13N氨后，对兔子的胸腹区域进行动态闪烁扫描。2）关于肝脏功能图像的理论思考：根据动物实验结果，提出了一个氨代谢模型，该模型具有在乙状结肠内给药情况下表示数据所需的最小复杂性。从描述该模型的微分方程的解出发，推导出了表征肝脏动态曲线的相关参数。
