White T G, Puls J L
J Bacteriol. 1969 May;98(2):403-6. doi: 10.1128/jb.98.2.403-406.1969.
A cell-free crude extract of Erysipelothrix rhusiopathiae injected by high pressure jet into the knee-joint of rabbits stimulated an acute, mild inflammatory reaction. Additional injections at 3-day intervals induced a chronic condition characterized by hyperplasia of the synovial cells and hypertrophy of the villi, due to infiltration by lymphocytes and plasma cells which formed aggregates resembling Allison-Ghormley bodies. There was also extensive proliferation of stroma vasculature and fibrous tissue. A similar jet injection of the diluent produced an early, transient, acute, and mild inflammation. A mechanism is postulated for fixation of one or more of the chemically characterized antigens in or near the synovium as a means of inducing the localized inflammatory response that predisposes the joint to infection.
将猪丹毒丝菌的无细胞粗提取物通过高压喷射注入兔膝关节，可引发急性轻度炎症反应。每隔3天进行额外注射会导致一种慢性病症，其特征为滑膜细胞增生和绒毛肥大，这是由于淋巴细胞和浆细胞浸润形成了类似Allison-Ghormley小体的聚集体。同时还存在基质血管系统和纤维组织的广泛增生。对稀释剂进行类似的喷射注射会产生早期、短暂、急性和轻度的炎症。推测一种机制是滑膜内或其附近固定一种或多种化学特征明确的抗原，以此诱导局部炎症反应，使关节易于感染。
