[Inhibitory effect of the calcium antagonist fendiline on digitalis glykosides induced contractions in the guinea pig terminal ileum (author's transl)].

The 10 mm muscle-strips from the guinea pig terminal ileum digitalis glycosides (0.4 microgram/ml beta-acetyl-digoxin or 0.5 microgram/ml k-strophanthin) induce contractions which are dose-dependently and reversibly prevented by the calcium antagonist N-(2-benzyl-ethyl)-N-(1-phenyl-ethyl)-amine hydrochloride (fendiline, Sensit) (0.01--1 microgram/ml). Therapeutic use of calcium antagonists for manifest symptoms of digitalis intoxication (diarrhoea, intestinal infarctions) is discussed as these symptoms may be caused by digitalis-induced increase of intracellular calcium ions.