七叶皂苷对大鼠的毒性及生育力研究（作者译）
[Studies on toxicity and fertility of escin in the rat (author's transl)].
作者信息
von Kreybig T, Prechtel K
出版信息
Arzneimittelforschung. 1977 Jul;27(7):1465-6.
PMID:578474
Abstract
The DL50 of escin was determined after i.p. application. Juvenile male rats were treated with 2X5 mg/kg escin at age 32 days. After they had reached fertility, kidneys, testes and sperm were examined. The high dose of escin used did not affect fertility and a nephrotoxic activity could not be detected either.
摘要
七叶皂苷的半数致死剂量（DL50）在腹腔注射给药后测定。32日龄的雄性幼鼠接受2×5mg/kg七叶皂苷的处理。待其达到生育能力后，对肾脏、睾丸和精子进行检查。所使用的高剂量七叶皂苷并未影响生育能力，也未检测到肾毒性活性。
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