Van Nevel C J, Henderickx H K, Demeyer D I, Martin J
Appl Microbiol. 1969 May;17(5):695-700. doi: 10.1128/am.17.5.695-700.1969.
Methane production from pyruvate by mixed rumen bacteria in vitro was nearly totally inhibited by chloral hydrate (0.1 mumole/ml of incubation fluid). This effect was accompanied by an accumulation of gaseous hydrogen and an increase in propionic acid production. Infusion of chloral hydrate (4 g/day) into the rumen of a sheep produced the same effects. Evidence is presented for a direct toxic effect of chloral hydrate upon methane bacteria. Results are discussed in terms of fermentation balances.
体外培养的混合瘤胃细菌利用丙酮酸产生甲烷的过程几乎完全被水合氯醛(0.1微摩尔/毫升培养液)抑制。这种作用伴随着气态氢的积累和丙酸生成的增加。向绵羊瘤胃中注入水合氯醛(4克/天)产生了相同的效果。有证据表明水合氯醛对产甲烷细菌有直接毒性作用。根据发酵平衡对结果进行了讨论。