Geelen J, Coert A, Meijer R, van der Vies J
Acta Endocrinol (Copenh). 1977 Sep;86(1):216-24. doi: 10.1530/acta.0.0860216.
The metabolism of testosterone undecanoate (TU) and testosterone (T) is studied in the gastrointestinal wall of the rat in vitro. A comparison is made with the in vivo metabolism of these compounds in the rat. The major metabolite first appearing during incubation of TU with the small intestine is T. Incubation of TU or T with the small intestine reveals a great similarity between the metabolite patterns obtained. This is also the case with the patterns derived from portal vein plasma upon oral administration of TU and T. Incubation of different parts of the gastrointestinal tract with TU or T shows that the greatest metabolic activity is located in the wall of the small intestine. Unlike T, TU is metabolized only to a small extent in the wall of the stomach and the large intestine.
在体外对大鼠胃肠道壁中十一酸睾酮（TU）和睾酮（T）的代谢进行了研究。并与这些化合物在大鼠体内的代谢情况作了比较。TU与小肠一起孵育时首先出现的主要代谢产物是T。TU或T与小肠一起孵育显示，所获得的代谢产物模式之间有很大的相似性。口服TU和T后门静脉血浆衍生的模式也是如此。用TU或T对胃肠道不同部位进行孵育表明，最大的代谢活性位于小肠壁。与T不同，TU在胃壁和大肠壁中仅少量代谢。
