伪狂犬病病毒感染期间核碱性蛋白的变化
Changes in nuclear basic proteins during pseudorabies virus infection.
作者信息
Stevens J G, Kado-Boll G J, Haven C B
出版信息
J Virol. 1969 May;3(5):490-7. doi: 10.1128/JVI.3.5.490-497.1969.
Abstract
As a preliminary study to investigation of the possible role played by basic proteins in the genetic regulation of virus-infected cells, acid-extractable proteins synthesized during pseudorabies virus infection were investigated. The synthesis of histones was found to decrease in a gradual manner, and arrest was complete by 6 hr after infection. Five virus-induced acid-extractable proteins appeared in nuclei of infected cells after 4 hr of infection. Four of these proteins were virus structural proteins; one was not. All these proteins contained tryptophan and, therefore, were not "classic" histones.
摘要
作为研究碱性蛋白在病毒感染细胞基因调控中可能作用的初步研究，对伪狂犬病病毒感染期间合成的酸可提取蛋白进行了研究。发现组蛋白的合成逐渐减少，感染后6小时完全停止。感染4小时后，五种病毒诱导的酸可提取蛋白出现在受感染细胞的细胞核中。其中四种蛋白是病毒结构蛋白，一种不是。所有这些蛋白都含有色氨酸，因此不是“经典”组蛋白。
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