Notes on the distribution of pseudo-exfoliation material with particular reference to the uveoscleral route of aqueous humour.

The distribution of pseudo-exfoliation material along the uveoscleral route of aqueous humour has been studied by electron microscopy. It turned out that such material is present only in the very first part of this exit pathway, i.e. in the innermost zone of the connective tissue bordering the anterior chamber angle. No pseudo-exfoliation material was observed between the ciliary muscle cells, in the suprachoroidal space or in the sclera. It is concluded that transport of pseudo-exfoliation material by flow of aqueous humour through the uveoscleral route to the bulbar and palpebral conjunctiva is improbable, and accordingly the pseudo-exfoliation material found in extrascleral tissue most likely arises in loco.