治疗剂量摄入后血清和尿液中匹莫林的定量测定（作者译）
[Quantitative determination of pemoline in serum and urine after ingestion of therapeutic doses (author's transl)].
作者信息
Goenechea S, Wagner G M
出版信息
Arzneimittelforschung. 1977;27(8):1604-5.
PMID:578754
Abstract
Serum and urine 5-phenyl-2-imino-4-oxazolidone (pemoline, Tradon) levels have been determined in normal subjects after therapeutic doses (40 mg). Peak levels in serum were reached within 4-6 h (1.1-1.5 mg/1). The half-life was 16-18 h. After the oral administration of 40 mg of pemoline 35-50% of the dose was excreted in urine within 32 h.
摘要
已测定正常受试者在服用治疗剂量（40毫克）后血清和尿液中5-苯基-2-亚氨基-4-恶唑烷酮（匹莫林，曲拉酮）的水平。血清中的峰值水平在4 - 6小时内达到（1.1 - 1.5毫克/升）。半衰期为16 - 18小时。口服40毫克匹莫林后，35 - 50%的剂量在32小时内从尿液中排出。
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