Satzinger G
Arzneimittelforschung. 1977;27(9a):1742-45.
Selection of a structurally confined group of diuretics out of 2-methylenethiazolidones-(4), a new class of compounds, and related heterocycles with partly choleretic properties is described. The physico-chemical parameters of ethyl (Z)-(3-methyl-4-oxo-5-piperidino-thiazolidin-2-ylidene) acetate (3; etozolin, Gö 687, Elkapin), which has been selected for therapeutic use, are discussed with respect to its close structural relation to the choleretic piprozoline (2). Both the spectroscopic results and the anomalous thermodynamic data of 2, 3 and the homologous compounds 4 and 5 demonstrate a structural specificity of 3 unknown up to now with diuretics.
从一类新型化合物2-亚甲基噻唑烷酮-（4）及具有部分利胆特性的相关杂环化合物中筛选出一组结构受限的利尿剂。已被选作治疗用途的乙酸乙酯（Z）-（3-甲基-4-氧代-5-哌啶基-噻唑烷-2-亚基）酯（3；依托唑啉，Gö 687，埃尔卡平），就其与利胆药匹普唑啉（2）的紧密结构关系进行了讨论。2、3以及同系化合物4和5的光谱结果和异常热力学数据均表明，3具有一种迄今为止利尿剂中未知的结构特异性。
