新型β-肾上腺素能受体阻断药物LB46的人体初步研究。
Preliminary investigations of a new beta-adrenoceptive receptor blocking drug, LB46, in man.
作者信息
Hill R C, Turner P
出版信息
Br J Pharmacol. 1969 Jun;36(2):368-72. doi: 10.1111/j.1476-5381.1969.tb09511.x.
Abstract
- Preliminary studies in man of a new beta-adrenoceptive receptor blocking drug, DL-4-(2-hydroxy-3-isopropylaminopropoxy)-indole (LB46), are described.2. LB46, 0.5 mg by oral administration, appeared to be of similar potency to propranolol 20 mg in inhibiting isoprenaline-induced and exercise-induced tachycardia.3. In comparable beta-receptor blocking doses LB46 did not show the negative chronotropic property possessed by propranolol.
摘要
本文描述了一种新型β-肾上腺素能受体阻断药物DL-4-(2-羟基-3-异丙氨基丙氧基)-吲哚（LB46）在人体中的初步研究。
口服0.5毫克LB46，在抑制异丙肾上腺素诱发的和运动诱发的心动过速方面，其效力似乎与20毫克普萘洛尔相似。
在相当的β受体阻断剂量下，LB46未表现出普萘洛尔所具有的负性变时特性。
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本文引用的文献
1
The effects of a new beta-adrenoceptive receptor blocking drug on heart rate in man.一种新型β-肾上腺素能受体阻断药对人体心率的影响。
Br J Pharmacol Chemother. 1968 Mar;32(3):663-70. doi: 10.1111/j.1476-5381.1968.tb00465.x.
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