Ata M
Postgrad Med J. 1969 May;45(523):319-22. doi: 10.1136/pgmj.45.523.319.
Three cases of defibrination syndrome and bleeding tendency are described. In each case the aetiology was completely different but thrombocytopenia and fibrinogenopenia were present together. This combination is invariably due to diffuse intravascular clotting and it is suggested that these simple investigations should be asked for in cases of unexplained shock, acute renal failure of obscure origin, severe intravascular haemolysis, septic abortions, etc. Heparin would appear to be of value in these cases of defibrination. However, if there is no thrombocytopenia, defibrination may be due to excessive fibrinolysis. This should be treated with anti-fibrinolytics only when an underlying clotting defect has been excluded.
本文描述了3例去纤维蛋白综合征及出血倾向病例。每例病因完全不同，但均同时存在血小板减少和纤维蛋白原减少。这种组合总是由于弥漫性血管内凝血所致，建议在不明原因休克、病因不明的急性肾衰竭、严重血管内溶血、感染性流产等病例中进行这些简单检查。肝素在这些去纤维蛋白病例中似乎有价值。然而，如果没有血小板减少，去纤维蛋白可能是由于过度纤溶所致。只有在排除潜在凝血缺陷后，才应用抗纤溶剂治疗。
