Inada Y, Nishikawa K, Nagaoka A, Kikuchi S
Arzneimittelforschung. 1977;27(9):1663-9.
The hypotensive and diuretic activities of a new diuretic, 1,4-dimorpholino-7-phenylpyrido[3,4-d] pyridazine (DS-511), were compared with those of hydrochlorothiazide (HC) in DOCA, renal and spontaneously hypertensive rats. The results obtained were: 1. During the developing stage of DOCA-hypertension the daily treatment of rats with DS-511 and HC showed significant hypotensive action. During this period the diuretic activity of both agents was clear. 2. During the equilibrium stage of DOCA-hypertension the hypotensive action of DS-511 was indistinct despite its diuretic activity. The hypotensive and diuretic action of HC was not clear. 3. In renal-hypertensive rats the daily treatment of DS-511 and HC caused significant, but weaker hypotension than that in the developing stage of DOCA-hypertension. In these animals the diuretic activity of both agents was clear. 4. In spontaneously hypertensive rats the daily treatment with DS-511 and HC exhibited a similar hypotensive and diuretic action. 5. In all three kinds of hypertensive rats the diuretic activity of DS-511 was similar to that of HC in the excretion of urine and sodium, but the former was less kaliuretic than the latter.
在去氧皮质酮（DOCA）性高血压大鼠、肾性高血压大鼠和自发性高血压大鼠中，对新型利尿剂1,4 - 二吗啉代 - 7 - 苯基吡啶并[3,4 - d]哒嗪（DS - 511）的降压和利尿活性与氢氯噻嗪（HC）进行了比较。得到的结果如下：1. 在DOCA性高血压的发展阶段，每日用DS - 511和HC治疗大鼠显示出显著的降压作用。在此期间，两种药物的利尿活性均明显。2. 在DOCA性高血压的平衡阶段，尽管DS - 511有其利尿活性，但其降压作用不明显。HC的降压和利尿作用不明显。3. 在肾性高血压大鼠中，每日用DS - 511和HC治疗引起显著的降压作用，但比DOCA性高血压发展阶段的降压作用弱。在这些动物中，两种药物的利尿活性均明显。 在自发性高血压大鼠中，每日用DS - 511和HC治疗表现出相似的降压和利尿作用。5. 在所有三种高血压大鼠中，DS - 511在尿和钠排泄方面的利尿活性与HC相似，但前者的排钾作用比后者弱。
