[大鼠注射促甲状腺激素后球后组织变化及各种药物的影响]

[Retrobulbular tissue changes following TSH administration and influence of various drugs in rats].

作者信息

Gatzke H D, Wildmeister W

出版信息

Endokrinologie. 1977 Sep;70(1):77-85.

Abstract

Our results demonstrate that the thyreotropin induced exophthalmus is a useful model for testing the efficacy of drugs in animal experiments. Concerning the exophthalmus producing tissue factors till now only qualitative results could be offered. Measuring the incorporation of 3H methionine the statements could be improved quantitatively. Hyaloronidase markedly reduced the thyreotropin induced exophthalmus. L-triiodothyronine, D-triiodothyronine. L-thyroxine, D-thyroxine and hydrocortisone had no certain influence on the TSH induced alterations.

摘要

我们的结果表明，促甲状腺素诱导的突眼症是在动物实验中测试药物疗效的有用模型。关于产生突眼症的组织因子，到目前为止只能提供定性结果。通过测量3H-甲硫氨酸的掺入量，可以在定量方面改进这些陈述。透明质酸酶显著降低了促甲状腺素诱导的突眼症。L-三碘甲状腺原氨酸、D-三碘甲状腺原氨酸、L-甲状腺素、D-甲状腺素和氢化可的松对促甲状腺激素诱导的改变没有确定的影响。

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