• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Blocking the encephalitogenic activity of the C-terminal part of the basic myelin protein in rabbits by treatment with serum.通过血清处理阻断兔碱性髓鞘蛋白C末端部分的致脑炎性活性。
Immunology. 1976 Apr;30(4):UNKNOWN.
2
Disease-inducing activity of different parts of bovine encephalitogenic protein in guinea-pigs.牛致脑炎性蛋白不同部位在豚鼠体内的致疾病活性
Neurobiology. 1975 Jun;5(3):137-50.
3
Neural antigens and induction of myelination inhibition factor.神经抗原与髓鞘形成抑制因子的诱导
J Immunol. 1975 Feb;114(2 Pt 1):630-4.
4
Protection against experimental allergic encephalomyelitis with peptides derived from myelin basic protein: presence of intact encephalitogenic site is essential.用髓鞘碱性蛋白衍生肽预防实验性变应性脑脊髓炎：完整致脑炎位点的存在至关重要。
J Immunol. 1976 Jul;117(1):110-4.
5
Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin antigens: IV. Suppression of chronic relapsing disease in the Lewis rat and strain 13 guinea pig.口服髓磷脂抗原对实验性自身免疫性脑脊髓炎的抑制作用：IV. 对Lewis大鼠和13号品系豚鼠慢性复发性疾病的抑制作用
Ann Neurol. 1991 Jun;29(6):615-22. doi: 10.1002/ana.410290608.
6
Specificity of antisera from Lewis rats immunized with encephalitogenic fragment 43-88 of guinea pig myelin basic protein.用豚鼠髓鞘碱性蛋白致脑炎片段43 - 88免疫的Lewis大鼠抗血清的特异性。
J Immunol. 1978 Nov;121(5):1865-9.
7
Antigen-induced inhibition of experimental allergic encephalomyelitis. III. Localization of an inhibitory site distinct from the major encephalitogenic determinant of myelin basic protein.抗原诱导的实验性变应性脑脊髓炎抑制作用。III. 与髓鞘碱性蛋白主要致脑炎决定簇不同的抑制位点的定位
J Immunol. 1975 Jan;114(1 Pt 1):191-4.
8
Enhancement of encephalitogenic activity by the formation of myelin basic protein-brain acidic protein complex.髓鞘碱性蛋白-脑酸性蛋白复合物的形成增强致脑炎活性。
Jpn J Exp Med. 1975 Oct;45(5):415-22.
9
[Therapeutic effect of myelin basic protein and synthetic encephalitogenic peptide in guinea pigs with experimental allergic encephalomyelitis].髓鞘碱性蛋白和合成致脑炎肽对实验性变应性脑脊髓炎豚鼠的治疗作用
Vopr Med Khim. 1978 May-Jun;24(3):372-7.
10
Inhibition of experimental allergic encephalomyelitis by carrier administered prior to challenge with encephalitogenic peptide-carrier conjugate.在用致脑炎肽-载体偶联物攻击之前给予载体对实验性变应性脑脊髓炎的抑制作用。
Eur J Immunol. 1981 Apr;11(4):335-8. doi: 10.1002/eji.1830110413.

本文引用的文献

1
Isolation and partial characterization of some proteolytically and chemically derived fragments of bovine encephalitogenic protein.牛致脑炎性蛋白某些经蛋白水解和化学衍生片段的分离及部分特性鉴定
Eur J Biochem. 1971 Jul 15;21(1):116-24. doi: 10.1111/j.1432-1033.1971.tb01447.x.
2
Experimental allergic encephalitis. Dissociation of cellular immunity to brain protein and disease production.实验性变应性脑脊髓炎。对脑蛋白的细胞免疫与疾病产生的分离。
J Exp Med. 1972 Jul 1;136(1):156-74. doi: 10.1084/jem.136.1.156.
3
Antigenic competition: a review of nonspecific antigen-induced suppression.抗原竞争：非特异性抗原诱导抑制的综述
Adv Immunol. 1974;18:133-68. doi: 10.1016/s0065-2776(08)60309-0.
4
Amino acid sequence of the smaller basic protein from rat brain myelin.大鼠脑髓鞘较小碱性蛋白的氨基酸序列。
Biochem J. 1974 Jul;141(1):243-55. doi: 10.1042/bj1410243.
5
A physiological mechanism preventing experimental allergic encephalitis.一种预防实验性变应性脑脊髓炎的生理机制。
Immunology. 1972 Sep;23(3):395-403.
6
Specific cleavage of the A1 protein from myelin with cathepsin D.组织蛋白酶D对髓磷脂中A1蛋白的特异性切割。
J Biol Chem. 1974 Jan 25;249(2):559-67.
7
Localization of antigenic determinants on bovine encephalitogenic protein further studies with the macrophage migration inhibition assay in guinea-pigs.
Immunochemistry. 1973 Sep;10(9):611-20. doi: 10.1016/0019-2791(73)90163-8.
8
Encephalitogenic activity in rabbits of the C-terminal region of bovine basic myelin protein.
Eur J Immunol. 1971 Dec;1(6):499-501. doi: 10.1002/eji.1830010621.
9
Allergic encephalomyelitis in monkeys induced by a peptide from the A1 protein.由A1蛋白的一种肽诱导的猴过敏性脑脊髓炎。
Proc Natl Acad Sci U S A. 1972 Mar;69(3):617-9. doi: 10.1073/pnas.69.3.617.
10
Allergic encephalomyelitis. Oxidation and cleavage of the single tryptophan residue of the A1 protein from bovine and human myelin.变应性脑脊髓炎。牛和人髓磷脂中A1蛋白单个色氨酸残基的氧化与裂解。
J Biol Chem. 1971 May 25;246(10):3425-30.

通过血清处理阻断兔碱性髓鞘蛋白C末端部分的致脑炎性活性。

Blocking the encephalitogenic activity of the C-terminal part of the basic myelin protein in rabbits by treatment with serum.

作者信息

Bergstrand H

出版信息

Immunology. 1976 Apr;30(4):UNKNOWN.

PMID:57920
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1445027/
Abstract

Peptides HNB-92-169 and 116-169, tyr, derivatives of the C-terminal part of bovine myelin basic protein, sensitize rabbits for experimental allergic encephalomyelitis (EAE). Dissolving these peptides in heat-inactivated normal guinea-pig, human, or monkey serum immediately before emulsification with Freund's complete adjuvant (FCA) abrogated their disease-inducing activity. Dissolving them in homologous or autologous serum only slightly affected the encephalitogenicity.

摘要

肽HNB - 92 - 169和116 - 169，即牛髓鞘碱性蛋白C末端部分的酪氨酸衍生物，可使家兔对实验性变态反应性脑脊髓炎（EAE）致敏。在用弗氏完全佐剂（FCA）乳化前，立即将这些肽溶解于热灭活的正常豚鼠、人或猴血清中，可消除它们的致疾病活性。将它们溶解于同种或自体血清中只会轻微影响其致脑炎活性。