通过血清处理阻断兔碱性髓鞘蛋白C末端部分的致脑炎性活性。
Blocking the encephalitogenic activity of the C-terminal part of the basic myelin protein in rabbits by treatment with serum.
作者信息
Bergstrand H
出版信息
Immunology. 1976 Apr;30(4):UNKNOWN.
Abstract
Peptides HNB-92-169 and 116-169, tyr, derivatives of the C-terminal part of bovine myelin basic protein, sensitize rabbits for experimental allergic encephalomyelitis (EAE). Dissolving these peptides in heat-inactivated normal guinea-pig, human, or monkey serum immediately before emulsification with Freund's complete adjuvant (FCA) abrogated their disease-inducing activity. Dissolving them in homologous or autologous serum only slightly affected the encephalitogenicity.
摘要
肽HNB - 92 - 169和116 - 169，即牛髓鞘碱性蛋白C末端部分的酪氨酸衍生物，可使家兔对实验性变态反应性脑脊髓炎（EAE）致敏。在用弗氏完全佐剂（FCA）乳化前，立即将这些肽溶解于热灭活的正常豚鼠、人或猴血清中，可消除它们的致疾病活性。将它们溶解于同种或自体血清中只会轻微影响其致脑炎活性。
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本文引用的文献
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Isolation and partial characterization of some proteolytically and chemically derived fragments of bovine encephalitogenic protein.牛致脑炎性蛋白某些经蛋白水解和化学衍生片段的分离及部分特性鉴定
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