Macadam R F
Br J Exp Pathol. 1969 Jun;50(3):239-40.
The early glomerular lesion of lead poisoning is illustrated in man and rabbits. The abnormality consists of complete epithelial cell foot process fusion and increased epithelial cell cytoplasmic density adjacent to a normal looking basement membrane. The basement membrane, although apparently morphologically undisturbed, is hyperpermeable to plasma proteins. Proteinuria in the early stage of lead poisoning is thus at least partly glomerular in origin.
铅中毒早期肾小球病变在人类和兔子身上都有体现。异常表现为完全的上皮细胞足突融合，以及在看似正常的基底膜附近上皮细胞胞质密度增加。基底膜虽然在形态上显然未受干扰，但对血浆蛋白具有高通透性。因此，铅中毒早期的蛋白尿至少部分源自肾小球。
