Regan T J, Passannante A J, Oldewurtel H A, Khan M I
Science. 1969 Aug 1;165(3892):509-10. doi: 10.1126/science.165.3892.509.
In dogs, pretreatment with the macrolide antibiotic tylosin (5 milligrams per day per kilogram of body weight) increased the incidence of ventricular tachycardia and fibrillation during acute myocardial ischemia. Another group received a dose of acetyl strophanthidin which was nontoxic in controls, but which resulted in a ventricular arrhythmia in six of seven animals on antibiotic treatment. Enhancement of loss of potassium ion from the myocardium by the antibiotic was presumed to be related to the altered cardiac rhythm.
在犬类中，用大环内酯类抗生素泰乐菌素（每千克体重每天5毫克）进行预处理会增加急性心肌缺血期间室性心动过速和颤动的发生率。另一组接受了一剂毒毛旋花子苷K，该剂量在对照组中无毒，但在接受抗生素治疗的7只动物中有6只导致了室性心律失常。据推测，抗生素增强心肌钾离子流失与心律改变有关。
