Jakobson I, Holmberg B, Wahlberg J E
Acta Pharmacol Toxicol (Copenh). 1977 Nov;41(5):497-506. doi: 10.1111/j.1600-0773.1977.tb02161.x.
The blood concentration of 1,1,2-trichloroethane was studied after epicutaneous application, by an intracutaneous, subcutaneous or intraperitoneal injection. An equation with three exponential terms was necessary for a satisfactory description of the experimental data in the case of intraperitoneal injection. Subcutaneous and intracutaneous injections seem to give essentially the same king of blood concentration curves as for intraperitoneal injection. In the case of percutaneous absorption an equation with three exponential terms and a constant was necessary to account for the experimental data. The complex toxicokinetics of 1,1,2-trichloroethane by percutaneous absorption was assumed to be associated with progressive skin damage observed in previously reported experiments, a damage apparently involving a change in barrier function.
通过皮内、皮下或腹腔注射后，研究了经皮应用1,1,2 - 三氯乙烷后的血药浓度。腹腔注射时，需要一个具有三个指数项的方程才能令人满意地描述实验数据。皮下和皮内注射产生的血药浓度曲线类型似乎与腹腔注射基本相同。经皮吸收时，需要一个具有三个指数项和一个常数的方程来解释实验数据。据推测，1,1,2 - 三氯乙烷经皮吸收的复杂毒代动力学与先前报道的实验中观察到的渐进性皮肤损伤有关，这种损伤显然涉及屏障功能的改变。
