Ritzmann H, Hillemanns H G
Arch Gynakol. 1977 Nov 29;223(4):345-56. doi: 10.1007/BF00667373.
In cases of endometrial carcinoma where hysterectomy was performed, we examined histologically the marginal endometrium. For comparison we formed a control group of women of the same age. In the age between 45 and 65 adenomatous hyperplasia in the cancer group is found significantly more often. The glandular-cystic hyperplasia is found more frequently in the age group beyond 55, especially in women beyond 65. The simultaneous incidence of adenomatous hyperplasia and endometrial carcinoma suggests this form of hyperplasia being precancerous. Before the menopause the glandular-cystic hyperplasia does not seem essential for the origin of the endometrial cancer. It is not yet known why the glandular-cystic hyperplasia is found more frequently in postmenopausal women with endometrial carcinoma. The role of the estrogenic hormones as agents possibly forming a good terrain for the endometrial cancer is discussed.
在接受子宫切除术的子宫内膜癌病例中,我们对边缘子宫内膜进行了组织学检查。为作比较,我们组建了一个同龄女性对照组。在45至65岁年龄段,癌组中腺瘤样增生的发现频率明显更高。腺囊性增生在55岁以上年龄组中更为常见,尤其是65岁以上的女性。腺瘤样增生与子宫内膜癌的同时发生表明这种增生形式具有癌前病变性质。绝经前,腺囊性增生似乎并非子宫内膜癌发生的必要因素。目前尚不清楚为何在患有子宫内膜癌的绝经后女性中腺囊性增生更为常见。文中讨论了雌激素作为可能为子宫内膜癌形成良好发病条件的因素所起的作用。