Jeejeebhoy K N
Can J Surg. 1978 Jan;21(1):17-8.
The conventional treatment of peptic ulcer disease with special dietary regimens, antacids or anticholinergics has been found wanting. Recently introduced agents show considerable promise in the benefit they can render. Carbenoxolone accelerates the healing of gastric ulcers by increasing gastric mucosal resistance. Cimetidine, a histamine HI-receptor antagonist, is an effective suppressant of acid secretion and therefore promotes healing of duodenal ulcers. Metoclopramide hastens gastric emptying and increases the tone of the gastroesophageal sphincter, and is valuable in cases of reflux esophagitis and gastric ulcer.
人们发现，采用特殊饮食疗法、使用抗酸剂或抗胆碱能药物对消化性溃疡疾病进行传统治疗存在不足。最近推出的药物在其所能带来的益处方面显示出相当大的前景。生胃酮通过增强胃黏膜抵抗力来加速胃溃疡的愈合。西咪替丁，一种组胺H1受体拮抗剂，是一种有效的胃酸分泌抑制剂，因此能促进十二指肠溃疡的愈合。甲氧氯普胺可加快胃排空并增强食管下括约肌的张力，在反流性食管炎和胃溃疡病例中很有价值。
