Mills D C, MacFarlane D E
Thromb Haemost. 1977 Dec 15;38(4):1010-7.
Suloctidil, a compound with antithrombotic properties in animal models, causes depletion of human platelet serotonin stores during 1-5 hr incubation with platelet-rich plasma in vitro. This effect is not attended by leakage of cytoplasmic nucleotides or by alterations in cyclic AMP metabolism, malondialdehyde production or energy balance. 5HT uptake was also inhibited but uptake of adenine was not. 5HT released by suloctidil appeared in the supernatant as oxidation products, though the amine also accumulated when re-uptake was blocked by imipramine.
舒洛地尔是一种在动物模型中具有抗血栓形成特性的化合物，在体外与富含血小板血浆孵育1 - 5小时期间，会导致人血小板5 - 羟色胺储备耗竭。这种效应不会伴随着细胞质核苷酸的泄漏，也不会伴随着环磷酸腺苷代谢、丙二醛生成或能量平衡的改变。5 - 羟色胺摄取也受到抑制，但腺嘌呤摄取未受影响。舒洛地尔释放的5 - 羟色胺以上清液中的氧化产物形式出现，不过当再摄取被丙咪嗪阻断时，该胺也会蓄积。
