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Effect of methotrexate on folate binding to a folate binding protein in cow's milk.

作者信息

Holm J, Hansen S I, Lyngbye J

出版信息

Acta Pharmacol Toxicol (Copenh). 1978 Jan;42(1):77-80. doi: 10.1111/j.1600-0773.1978.tb02172.x.

DOI:10.1111/j.1600-0773.1978.tb02172.x
PMID:579715
Abstract

Folate in cow's milk was strongly bound to a minor whey protein. Methotrexate inhibited the folate binding in a log dosis dependent manner, but was a rather weak inhibitor. The binding mechanism of folate changed from a cooperative to a non-cooperative type in the presence of methotrexate. This model system could be used in investigations on human body fluids and tissues.

摘要

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