三环类抗抑郁药中毒时的心脏异常
Cardiac abnormalities in poisoning with tricyclic antidepressants.
作者信息
Freeman J W, Mundy G R, Beattie R R, Ryan C
出版信息
Br Med J. 1969 Jun 7;2(5657):610-1. doi: 10.1136/bmj.2.5657.610.
Abstract
Of 80 consecutive admissions to a general hospital for drug overdose, 10 had taken one or other of the tricyclic antidepressants. All 10 had abnormalities of cardiac conduction as shown by prolonged Q-T(e) intervals, and eight had S-T segment and T-wave changes. Five of the 10 patients had arrhythmias and two of these died. Continuous electrocardiographic monitoring is recommended in patients with overdosage of tricyclic antidepressants.
摘要
在一家综合医院连续收治的80例药物过量患者中，有10例服用了一种或多种三环类抗抑郁药。所有10例患者均有心脏传导异常，表现为Q-T（e）间期延长，8例有S-T段和T波改变。10例患者中有5例出现心律失常，其中2例死亡。建议对三环类抗抑郁药过量患者进行连续心电图监测。
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