[Synthesis of Butyl 6alpha-Fluoro-11beta-hydroxy-16alpha-methyl-3,20-dioxo-1,4-pregnadien-21-oate (Fluocortin Butylester) (author's transl)].
作者信息
Laurent H, Gerhards E, Wiechert R
出版信息
Arzneimittelforschung. 1977;27(11a):2187-8.
PMID:580026
Abstract
Among the metabolites of fluocortolone (1) there was found the alpha-keto acid 4a. This acid, as well as the esters 4b--4k were synthesized and the butyl ester 4c was chosen for local anti-inflammatory therapy.
摘要
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1
[Synthesis of Butyl 6alpha-Fluoro-11beta-hydroxy-16alpha-methyl-3,20-dioxo-1,4-pregnadien-21-oate (Fluocortin Butylester) (author's transl)].
Arzneimittelforschung. 1977;27(11a):2187-8.
2
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[Effect of fluocortin butylester (0.75%) as an ointment in the pyrexal erythema test on human skin (author's transl)].
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Arzneimittelforschung. 1977;27(11a):2191-202.
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10
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