从大鼠尿液中分离并确定2-(1,3-二甲基-黄嘌呤基-(7)-甲基)-4-甲基-吗啉——一种黄嘌呤醇衍生物——的代谢产物（作者译）
[Isolation and structure determination of the metabolites of 2-(1,3-dimethyl-xanthinyl-(7)-methyl)-4-methyl-morpholine--a xantinol derivative--from rat urine (author's transl)].
作者信息
Tauscher M, Eckhardt G, Geisel B, Schroeder G
出版信息
Arzneimittelforschung. 1977;27(12):2344-7.
PMID:580049
Abstract
In the urine of rats the following metabolites of the xantinol derivative 2-(1,3-dimethyl-xanthinyl-(7)-methyl)-4-methyl-morpholine were found: 2-[1,3-dimethyl-xanthinyl-(7)-methyl]-morpholine and 2-[1,3-dimethyl-xanthinyl-(7)-methyl]-4-methyl-morpholin-5-one. These compounds represent about 13.7% of the p.o. applied 2-[1,3-dimethyl-xanthinyl-(7)-methyl]-4-methyl-morpholine. Their structure has been elucidated by IR-, PMR- and mass spectrometry.
摘要
在大鼠尿液中发现了黄嘌呤醇衍生物2-(1,3-二甲基-黄嘌呤基-(7)-甲基)-4-甲基-吗啉的以下代谢产物：2-[1,3-二甲基-黄嘌呤基-(7)-甲基]-吗啉和2-[1,3-二甲基-黄嘌呤基-(7)-甲基]-4-甲基-吗啉-5-酮。这些化合物约占口服给予的2-[1,3-二甲基-黄嘌呤基-(7)-甲基]-4-甲基-吗啉的13.7%。它们的结构已通过红外光谱、核磁共振氢谱和质谱得以阐明。
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