Comparative study of oxaflozane urinary metabolism in man, the dog and the rat. Identification of the principal metabolites.

The urinary metabolites of isopropyl-4-(trifluoromethyl-3-phenyl)-2-morpholine (oxaflozane) were compared in man, the dog and the rat using thin-layer chromatography and gas chromatography. In the dog, the tritiated molecule on the morpholine ring was administered to a certain number of animals. The principal metabolites were isolated, purified and identified by IR, RMN spectrometry and mass spectrometry. The principal metabolite in man and the rat was obtained by osaflozane N-dealkylation. In the dog, 2 metabolites formed by cleavage of the morpholine ring were also observed.