在人体中，DES-ASP1-、ILEU8-血管紧张素II对血管紧张素III作用的抑制。

Inhibition of angiotensin III action by DES-ASP1-,ILEU8-angiotensin II in man.

作者信息

Kono T, Ikeda F, Oseko F, Nanno M, Imura H, Endo J

出版信息

Acta Endocrinol (Copenh). 1978 Feb;87(2):359-66. doi: 10.1530/acta.0.0870359.

DOI:10.1530/acta.0.0870359

Abstract

In 5 normal men intravenous infusion of 600 ng/kg/min of des-asp1-ileu8-angiotensin II (AIIIA) inhibited a rise in blood pressure as well as increase in plasma aldosterone caused by an intravenous infusion of 20 or 100 ng/kg/min of des-asp1-angiotensin II (angiotensin III, AIII). This result and our previous study on simultaneous infusions of 600 ng/kg/min of AIIIA and 20 ng/kg/min of angiotensin II (AII) in the same 5 normal men demonstrate that this dose of AIIIA antagonizes AIII and AII on the adrenal cortex as well as peripheral arterioles and that AIIIA has the same degree of inhibitory effect on the aldosterone-stimulating action of AIII and on that of AII in man.

摘要

在5名正常男性中，静脉输注600 ng/kg/min的去天门冬氨酸-异亮氨酸8-血管紧张素II（AIIIA）可抑制静脉输注20或100 ng/kg/min的去天门冬氨酸-血管紧张素II（血管紧张素III，AIII）所引起的血压升高以及血浆醛固酮增加。该结果以及我们之前在这5名相同正常男性中同时输注600 ng/kg/min的AIIIA和20 ng/kg/min的血管紧张素II（AII）的研究表明，此剂量的AIIIA在肾上腺皮质以及外周小动脉上拮抗AIII和AII，并且AIIIA对人AIII的醛固酮刺激作用和对AII的醛固酮刺激作用具有相同程度的抑制效果。