Hou S M, Lipscomb D M
Arch Otorhinolaryngol. 1978 Jan 30;218(3-4):239-45. doi: 10.1007/BF00455558.
Anesthestized chinchilla with round window electrodes were placed in a Plexiglas chamber. When they inhaled 100% oxygen at 1 atm, two types of neural effects were observed: 1. fast and reversible AP depression in response to brief exposure to 100% O2; and 2. a slowly developed chronic depression of AP and latency shift due to multiple hyperoxic exposures. The severity of the latter is a function of the dosage of the O2 inhaled, i.e., the concentration of oxygen and the length of time of exposure. For the type-1 effect, carbon dioxide deprivation is felt to be the immediate cause while the type-2 effect is mainly due to O2 toxicity developed at the intracellular level by high O2 concentration. The possible role of superoxide in the auditory O2 toxicity was discussed.
将带有圆窗电极的麻醉后的毛丝鼠置于有机玻璃腔室中。当它们在1个大气压下吸入100%氧气时，观察到两种神经效应：1. 对短暂暴露于100%氧气的反应是快速且可逆的动作电位（AP）抑制；2. 由于多次高氧暴露导致动作电位的慢性抑制和潜伏期延长。后者的严重程度是吸入氧气剂量的函数，即氧气浓度和暴露时间的长短。对于1型效应，认为二氧化碳缺乏是直接原因，而2型效应主要是由于高氧浓度在细胞内水平产生的氧毒性。讨论了超氧化物在听觉氧毒性中的可能作用。
